abstract：OBJECTIVES:Cognitive impairment is frequent in children with frontal lobe epilepsy (FLE). Its etiology remains unknown. With diffusion tensor imaging, we have studied cerebral white matter properties and associations with cognitive functioning in children with FLE and healthy controls. METHODS:Thirty children aged 8-1...

journal_title：Acta neurologica Scandinavica

authors： Braakman HM,Vaessen MJ,Jansen JF,Debeij-van Hall MH,de Louw A,Hofman PA,Vles JS,Aldenkamp AP,Backes WH

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Hereditary haemorrhagic telangiectasia (HHT) is a dominantly inherited disease characterized by a wide variety of clinical manifestations, including pulmonary arteriovenous malformations (PAVMs), which due to paradoxical embolization may cause cerebral abscess. OBJECTIVE:To estimate the risk of cerebral abs...

journal_title：Acta neurologica Scandinavica

authors： Kjeldsen AD,Tørring PM,Nissen H,Andersen PE

更新日期：2014-03-01 00:00:00

abstract：AIMS:To conduct a psychometric analysis to determine the adequacy of instruments that measure cognition in Alzheimer's disease trials. BACKGROUND:Both the Alzheimer's Disease Assessment Scale - Cognition (ADAS-Cog) and the Neuropsychological Test Battery (NTB) are validated outcome measures for clinical trials in Alzh...

journal_title：Acta neurologica Scandinavica

authors： Karin A,Hannesdottir K,Jaeger J,Annas P,Segerdahl M,Karlsson P,Sjögren N,von Rosen T,Miller F

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:Obstructive sleep apnea syndrome (OSAS) is characterized in polysomnography by recurrent airflow obstruction during sleep. The underlying pathogenic mechanisms of neuropsychological and cerebrovascular events in patients with OSAS have not been clarified unequivocally. MATERIAL AND METHODS:Case-control st...

journal_title：Acta neurologica Scandinavica

authors： Jiménez Caballero PE,Coloma Navarro R,Segura Martín T,Ayo Martín O

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:There is paucity of information about the association of seizure severity and quality of life in people with epilepsy (PWE) in sub-Saharan Africa. We evaluated the relationship of seizure severity to health-related quality of life of patients with epilepsy being followed up in an outpatient neurology clinic ...

journal_title：Acta neurologica Scandinavica

authors： Adebayo PB,Akinyemi RO,Ogun SA,Ogunniyi A

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:In this follow-up study, we wanted to present the long-term outcome (5-21 years) in terms of seizure freedom, seizure reduction, and the cognitive development in the first 47 children who underwent epilepsy surgery at the University Hospital in Lund from 1991 to 2007. MATERIALS AND METHODS:All children who ...

journal_title：Acta neurologica Scandinavica

authors： Hallböök T,Tideman P,Rosén I,Lundgren J,Tideman E

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:Biomarkers with the potential for longitudinal measurements are needed in multiple sclerosis (MS). Urine is easy to collect, and repeated sampling is possible. METHODS:39 paired CSF and urine samples were taken. Oligoclonal bands (OCBs) were measured in CSF. Kappa and lambda free light chain (FLC), neopteri...

journal_title：Acta neurologica Scandinavica

authors： Dobson R,Topping J,Davis A,Thompson E,Giovannoni G

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:Our purpose was to identify the incidence and significance of markers of systemic connective tissue abnormalities (CTA) in patients with saccular intracranial aneurysms (SIA). MATERIALS AND METHODS:This prospective case-control study included 199 consecutive patients with SIA (103 women and 96 men, mean age...

journal_title：Acta neurologica Scandinavica

authors： Lebedeva ER,Sakovich VP

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Neuropsychiatric symptoms are common in Parkinson's disease and may precede onset of motor symptoms. They are also known to increase caregiver's burden. OBJECTIVE:The aim of this study was to assess neuropsychiatric symptoms in a cohort of Nigerian patients with idiopathic Parkinson's disease and compare wi...

journal_title：Acta neurologica Scandinavica

authors： Ojagbemi AA,Akinyemi RO,Baiyewu O

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:Hospital admission in otherwise healthy patients following a first unprovoked seizure is controversial. We aimed to evaluate the influence of admission in a neurology department on the identification of risk factors for seizure recurrence in patients with a first unprovoked seizure. MATERIALS AND METHODS:We...

journal_title：Acta neurologica Scandinavica

authors： Goldberg I,Neufeld MY,Auriel E,Gandelman-Marton R

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:Although patients >80 years were excluded in RCTs for tPA treatment of acute ischemic stroke (AIS), many centers treat old patients. We wanted to examine whether age ≥80 years is an independent predictor of outcome after tPA. MATERIALS:We included 77 consecutive patients ≥80 years and 83 patients <80 years t...

journal_title：Acta neurologica Scandinavica

authors： Henriksen EH,Ljøstad U,Tveiten A,Naess H,Thomassen L,Mygland A

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:Optic neuritis (ON) often precedes multiple sclerosis (MS). MS is associated with a significant socioeconomic burden. However, the burden of ON with and without MS before and after its diagnosis has never been calculated. METHODS:Using complete national records from the Danish National Patient Registry (199...

journal_title：Acta neurologica Scandinavica

authors： Jennum P,Frederiksen JL,Wanscher B,Kjellberg J

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVES:To study the prevalence of antibodies of IgA class against tissue transglutaminase (tTG), endomysium (EMA) and gliadin (AGA) in patients with chronic idiopathic axonal polyneuropathy (CIAP) and to characterize the patients clinically and neurophysiologically. METHODS:Of 182 patients, 126 patients agreed to ...

journal_title：Acta neurologica Scandinavica

authors： Vrethem M,Lindh J,Tondel M,Persson B,Dahle C

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVES:An oral dispersible microtablet formulation of levodopa/carbidopa 5/1.25 mg (LC-5) was developed for individualized repeated dosing. The aim was to compare pharmacokinetic profiles of LC-5 and levodopa/carbidopa/entacapone (LCE). MATERIALS AND METHODS:A randomized, crossover study was carried out in 11 heal...

journal_title：Acta neurologica Scandinavica

authors： Nyholm D,Ehrnebo M,Lewander T,Trolin CG,Bäckström T,Panagiotidis G,Spira J,Nyström C,Aquilonius SM

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate risk factors separately and in sum in relation to long-term mortality after arterial cerebral infarction in young adults. MATERIALS AND METHODS:Mortality in relation to the number of risk factors (smoking, hypertension, hypercholesterolemia, diabetes mellitus, myocardial infarction...

journal_title：Acta neurologica Scandinavica

authors： Naess H,Waje-Andreassen U,Nyland H

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVES:Dopamine neurotransmission is a critical factor for executive function, which is controlled by the prefrontal cortex in humans. Although the contribution of genetic factors to the regulation of brain dopaminergic activity is widely acknowledged, identification of a genotype-phenotype association has not yet ...

journal_title：Acta neurologica Scandinavica

authors： Mitaki S,Isomura M,Maniwa K,Yamasaki M,Nagai A,Nabika T,Yamaguchi S

更新日期：2013-01-01 00:00:00

abstract：:Carotid stenoses of ≥50% account for about 15-20% of strokes. Their degree may be moderate (50-69%) or severe (70-99%). Current diagnostic methods include ultrasound, MR- or CT-angiography. Stenosis severity, irregular plaque surface, and presence of microembolic signals detected by transcranial Doppler predict the ea...

journal_title：Acta neurologica Scandinavica

authors： Momjian-Mayor I,Burkhard P,Murith N,Mugnai D,Yilmaz H,Narata AP,Lovblad K,Pereira V,Righini M,Bounameaux H,Sztajzel RF

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:Evaluate interim long-term tolerability, safety and efficacy of adjunctive perampanel, a novel α-amino-3-hydroxy-5-methyl-5-isoxazolepropionic acid (AMPA)-receptor antagonist, in patients with refractory partial-onset seizures. MATERIALS AND METHODS:Study 207, an open-label extension (OLE) study (ClinicalTr...

journal_title：Acta neurologica Scandinavica

authors： Rektor I,Krauss GL,Bar M,Biton V,Klapper JA,Vaiciene-Magistris N,Kuba R,Squillacote D,Gee M,Kumar D

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVES:The differential diagnosis of patients with idiopathic parkinsonism is difficult, especially early in the course of the disease. External anal sphincter electromyography (EAS-EMG) has been reported to be of value in the differential diagnosis between Parkinson's disease (PD) and multiple system atrophy (MSA)...

journal_title：Acta neurologica Scandinavica

authors： Linder J,Libelius R,Nordh E,Holmberg B,Stenlund H,Forsgren L

更新日期：2012-10-01 00:00:00

abstract：:Vigabatrin (VGB), an irreversible inhibitor of gamma-aminobutyric acid (GABA) transaminase, is approved as adjunct treatment of refractory partial seizures as well as infantile spasms. Although VGB has been proven to be effective, its use is limited by the risk of retinopathy and associated peripheral visual field def...

journal_title：Acta neurologica Scandinavica

authors： Heim MK,Gidal BE

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVES:Until now, the significance of plasma exchange (PE) as a treatment for steroid-unresponsive optic neuritis (ON) is still unclear because placebo-controlled and larger studies are missing. We report our experience with 23 patients treated by PE due to steroid-unresponsive ON. MATERIALS AND METHODS:Patients w...

journal_title：Acta neurologica Scandinavica

authors： Roesner S,Appel R,Gbadamosi J,Martin R,Heesen C

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Treatment with lamotrigine (LTG) during pregnancy is associated with a pronounced risk of seizure deterioration, because pregnancy accelerates LTG elimination. The extent to which pregnancy affects LTG pharmacokinetics is unpredictable and varies considerably among patients. AIM:We propose an algorithm for ...

journal_title：Acta neurologica Scandinavica

authors： Sabers A

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVES:Differential diagnosis between vascular parkinsonism (VP) and Parkinson's Disease (PD) is often difficult, due to the overlap in clinical presentation and the lack of specificity at neuroimaging. Aim of the study was to identify a possible reliable marker at SPECT imaging useful to distinguish the two condit...

journal_title：Acta neurologica Scandinavica

authors： Contrafatto D,Mostile G,Nicoletti A,Dibilio V,Raciti L,Lanzafame S,Luca A,Distefano A,Zappia M

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Early administration of paracetamol may improve outcome of patients with acute stroke and a baseline body temperature of 37°C or above by lowering body temperature and preventing fever. Besides its antipyretic effects, paracetamol may affect blood pressure through cyclooxygenase-2 inhibition. We therefore ai...

journal_title：Acta neurologica Scandinavica

authors： den Hertog HM,van der Worp HB,van Gemert HM,van Gijn J,Koudstaal PJ,Dippel DW

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:The Danish National Patient Register, Landspatientregistret (LPR), is a register of all hospital discharges and outpatient treatments in Denmark. AIMS:It is increasingly used in research so it is important to understand to what extent this can be used as an accurate source of information. Virtually all pati...

journal_title：Acta neurologica Scandinavica

authors： Mason K,Thygesen LC,Stenager E,Brønnum-Hansen H,Koch-Henriksen N

更新日期：2012-03-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to examine the coping strategies of 49 patients with amyotrophic lateral sclerosis (ALS) and their relationships with medical and demographic data. METHODS:A total of 49 subjects were asked to fill out a document that would provide their demographic and medical data. Then, each o...

journal_title：Acta neurologica Scandinavica

authors： Montel S,Albertini L,Spitz E

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that status epilepticus can lead to neuronal injury. However, the effect of a small number of isolated seizures is uncertain. METHODS:We used structural MRI and neuropathology to study the effects of isolated seizures induced by kainic acid (KA), (RS)-2-amino-3-(3-hydroxy-5-tert-...

journal_title：Acta neurologica Scandinavica

authors： Acosta MT,Munashinge J,Zhang L,Guerron DA,Vortmeyer A,Theodore WH

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:Patients with multiple sclerosis were reported to harbour antibodies not only against proteins and glycoproteins but also against glycolipids, including sulfatide and galactosylceramide (GalCer), the two major glycosphingolipids of myelin. However, previous results were inconsistent concerning glycosphingoli...

journal_title：Acta neurologica Scandinavica

authors： Haghighi S,Lekman A,Nilsson S,Blomqvist M,Andersen O

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:The prognosis after Lyme neuroborreliosis (LNB) is debated. The aim of this study was to assess health-related Quality of Life (QoL) and neurological symptoms 30 months after treatment in European patients with LNB. MATERIALS AND METHODS:In a prospective case-control designed study, we investigated 50 well-...

journal_title：Acta neurologica Scandinavica

authors： Eikeland R,Mygland A,Herlofson K,Ljøstad U

更新日期：2011-11-01 00:00:00

abstract：:OBJECTIVES - Determine whether bilateral subthalamic nucleus stimulation (STN-DBS) in Parkinson's disease (PD) is associated with an increase in neuropeptide Y (NPY) and/or resistance to inhibition by leptin in relation to post-surgery weight gain. MATERIALS AND METHODS - This prospective study included 20 patients wh...

journal_title：Acta neurologica Scandinavica

authors： Escamilla-Sevilla F,Pérez-Navarro MJ,Muñoz-Pasadas M,Sáez-Zea C,Jouma-Katati M,Piédrola-Maroto G,Ramírez-Navarro A,Mínguez-Castellanos A

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:No systematic study has been made to separate age-related clinical deterioration and dysfunctional brain areas from those associated with Parkinson's disease (PD). METHODS:This study included 73 de novo patients with PD and 43 age-matched controls. All subjects underwent [(18)F]-fluorodeoxy glucose (FDG) po...

journal_title：Acta neurologica Scandinavica

authors： Lee MS,Lyoo CH,Ryu YH,Lim HS,Nam CM,Kim HS,Rinne JO

更新日期：2011-09-01 00:00:00

abstract：:There has been considerable interest in the possible association between impaired glucose tolerance (IGT) and neuropathy. A systematic literature search (Medline) and review was here performed. Twenty-three studies were evaluated. Fourteen investigated for the presence of neuropathy in patients with IGT. Nine studied ...

journal_title：Acta neurologica Scandinavica

authors： Rajabally YA

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:Cerebrospinal fluid (CSF) pressure-volume compensation may change over time as part of normal ageing, where the resistance to CSF outflow increases and the formation of CSF decreases with age. Is CSF compensation dependent on duration of symptoms in idiopathic normal pressure hydrocephalus (iNPH)? METHODS:We...

journal_title：Acta neurologica Scandinavica

authors： Czosnyka Z,Owler B,Keong N,Santarius T,Baledent O,Pickard JD,Czosnyka M

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:For most major antiepileptic drugs, neuropsychological side effects have been reported. Healthy volunteer studies have found that both carbamazepine and valproate impair aspects of verbal memory. OBJECTIVE:The aim of this study was to assess the effects of carbamazepine and valproate on verbal memory, in a ...

journal_title：Acta neurologica Scandinavica

authors： Hessen E,Lossius MI,Gjerstad L

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVES:To estimate dementia prevalence in Spain. MATERIALS AND METHODS:Nine probabilistic and geographically defined samples participated. A screening design based on the MMSE was implemented. Positively screened individuals underwent clinical evaluation. The total number of cases in Spain was estimated. Prevalenc...

journal_title：Acta neurologica Scandinavica

authors： Virués-Ortega J,de Pedro-Cuesta J,Vega S,Seijo-Martínez M,Saz P,Rodríguez F,Rodríguez-Laso A,Reñé R,de Las Heras SP,Mateos R,Martínez-Martín P,Mahillo-Fernández I,López-Pousa S,Lobo A,Reglà JL,Gascón J,García FJ,Fernánd

更新日期：2011-05-01 00:00:00

abstract：:Decompressive craniectomy is a neurosurgical technique in which a portion of the skull is removed to reduce intracranial pressure. The rationale for this procedure is based on the Monro-Kellie Doctrine; expanding the physical space confining edematous brain tissue after traumatic brain injury will reduce intracranial ...

journal_title：Acta neurologica Scandinavica

authors： Quinn TM,Taylor JJ,Magarik JA,Vought E,Kindy MS,Ellegala DB

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVES:To re-evaluate middle-aged Swedish patients diagnosed with dysequilibrium syndrome (DES) in childhood and to compare their clinical and neuroimaging features to DES with VLDLR gene mutations (DES-VLDR). MATERIALS AND METHODS:Six patients from five families underwent neurological examination and magnetic res...

journal_title：Acta neurologica Scandinavica

authors： Melberg A,Orlén H,Raininko R,Entesarian M,Dahlqvist J,Gustavson KH,Dahl N

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To investigate changes and regional variations in annual incidence rates of aneurysmal subarachnoid hemorrhage (SAH) in Norway between 1999 and 2007. METHODS:The authors retrospectively reviewed data from the Norwegian Patient Register for the period 1999-2007. RESULTS:Crude incidence of aneurysmal SAH was ...

journal_title：Acta neurologica Scandinavica

authors： Lindekleiv HM,Njølstad I,Ingebrigtsen T,Mathiesen EB

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Idiopathic peripheral facial nerve palsy or Bell's palsy (BP) is the most common cause of facial nerve palsy. OBJECTIVE:To evaluate the role of glucose metabolism abnormalities in BP. METHODS:We identified 148 patients with unilateral BP and 128 control subjects. In all we evaluated glucose level at fastin...

journal_title：Acta neurologica Scandinavica

authors： Bosco D,Plastino M,Bosco F,Consoli A,Labate A,Pirritano D,Consoli D,Fava A

更新日期：2011-01-01 00:00:00

abstract：:The use of high-dose polyclonal intravenous immunoglobulin (IVIG) in the treatment of autoimmune neurological diseases has expanded over the last decade. Based on controlled clinical trials IVIG can be considered currently as the first-line treatment in Guillain-Barré syndrome, chronic inflammatory demyelinating polyn...

journal_title：Acta neurologica Scandinavica

authors： Elovaara I,Hietaharju A

更新日期：2010-11-01 00:00:00